Mechanisms of Antineoplastic Action of Somatostatin Analogs
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چکیده
منابع مشابه
Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine.
Ellipticine is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. This article reviews the mechanisms of predominant pharmacological and cytotoxic effects of ellipticine and shows the results of our laboratories indicating a novel mechanism of its action. The prevalent mechanisms of ellipticine antitumor, mutagenic and cytotoxic activities were suggested to be inte...
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Arsenic-based compounds have become accepted agents for cancer therapy providing high rates of remission of some cancers such as acute promyelocytic leukemia (APL). The mechanisms by which arsenic-containing compounds kill cells and reasons for selective killing of only certain types of cancer cells such as APLs have recently been delineated. This knowledge was gained in parallel with increasin...
متن کاملSomatostatin analogs: future directions.
S OMATOSTATIN is involved in the negative control of the normal function of a number of organ systems. One might call the peptide an inhibitory tissue (growth) factor, which mainly prevents local overreaction from a multitude of stimulatory factors. Long-term administration of somatostatin analogs in most instances only transiently inhibits physiological actions, either because of their desensi...
متن کاملCellular mechanisms of somatostatin action in the gut.
We have used isolated canine parietal cells to examine the receptor and postreceptor events mediating the inhibitory effects of somatostatin on acid secretion. Somatostatin-14 (S14) and somatostatin-28 (S28) dose dependently inhibited parietal cells stimulated by secretagogues that activate both the adenylate cyclase/cyclic adenosine monophosphate and the inositol phospholipid/protein kinase C ...
متن کاملProgressive nuclear translocation of somatostatin analogs.
UNLABELLED Optimal cancer radiotherapy using Auger electron emitters requires selective localization of radionuclides in close proximity to tumor DNA. METHODS Intracellular trafficking of (125)I-Tyr1-somatostatin-14 somatotropin-release inhibiting factor (SRIF) and 2 of its analogs, (125)I-WOC 4a and (111)In-pentetreotide, was studied in human neuroblastoma cells. RESULTS After 24-h incubat...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 1998
ISSN: 1535-3702,1535-3699
DOI: 10.3181/00379727-217-44216